Multiple subcellular localizations and functions of protein kinase Cδ in liver cancer

Figure 1 Schematic representation of protein kinase Cδ domains. The N-terminal regulatory domain is composed of 1 to 329 amino acids, non-functional C2, pseudosubstrate, and lipid binding C1 (a and b) domains. The C-terminal catalytic domain is composed of 330 to 676 amino acids, ATP-binding C3, and kinase C4 domains. The 329 amino acids at the V3 region allow the cleavage site by caspase-3 to be constitutively active. The V5 region includes nuclear localization signal necessary for the nuclear transport of protein kinase Cδ. NLS: Nuclear localization signal.