Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach

Table 3 Nucleotide variations in the 5’-regulatory (-584 to +107) region of tumor necrosis alpha in Sudanese Helicobacter pylori-infected patients

SNP	Event	SNP locus1	Chromosomeposition	Serialnumber (rs)
C>G (homozygous)	Transversion	-567	NG_007462.1:g.4422 C>G	rs2857711
G>A (heterozygous)	Transition	-375	NG_007462.1:g.4614 G>A	rs1800750
G>A (heterozygous and homozygous)	Transition	-307	NG_007462.1:g.4682 G>A	rs1800629
G>A (heterozygous)	Transition	-237	NG_007462.1:g.4752 G>A	rs361525
T>A (heterozygous)	Transversion	-76	NG_007462.1:g.4913 T>A	rs41297589
A>T (heterozygous)	Transversion	+27	NG_007462.1:g.5016 A>T2	-
Insertion of C	-	+70	NG_007462.1:g.5058-5059 InsC	-

¹Position of the single nucleotide polymorphism is relative to the tumor necrosis factor-alpha mRNA cap site[26].

²Novel mutation at the 5’ untranslated region detected in this study. SNP: Single nucleotide polymorphism.