Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach

doi:10.3748/wjg.v28.i2.242

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2022; 28(2): 242-262
Published online Jan 14, 2022. doi: 10.3748/wjg.v28.i2.242

Table 10 Tumor necrosis factor-alpha-1030 polymorphism and gastric cancer association risk in gastric cancerous patients and subjects with benign gastric disorders, n (%)

	Gastric pathologies		OR (95%CI)
	Benign disorders¹*, n* = 108	Cancer, n = 14	OR (95%CI)
Allele frequency
TNF-A-1030-T	176 (90.28)	21 (75.00)	1.150 (0.4627 - 2.8600)
TNF-A-1030-C	51 (9.72)	7 (25.00)	1.150 (0.4627 - 2.8600)
P value	0.8116
Genotype frequency
T/T	68 (62.96)	7 (50.00)	1.700 (0.5556 - 5.2020)
C carrier	40 (37.04)	7 (50.00)	1.700 (0.5556 - 5.2020)
P value	0.3900

¹Benign disorders, i.e. gastritis, duodenitis or ulcer.

OR: Odds ratio; 95%CI: 95% confidence interval; TNF-A: Tumor necrosis factor-alpha.

Citation: Idris AB, Idris AB, Gumaa MA, Idris MB, Elgoraish A, Mansour M, Allam D, Arbab BM, Beirag N, Ibrahim EAM, Hassan MA. Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach. World J Gastroenterol 2022; 28(2): 242-262
URL: https://www.wjgnet.com/1007-9327/full/v28/i2/242.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i2.242