Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study

Table 7 Univariate and multivariate analysis of risk factors for pancreatitis and bleeding

	Pancreatitis				Bleeding
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Age, > 65 yr	0.722 (0.225-2.323)	0.585			0.753 (0.206-2.745)	0.667
Sex, Male	1.486 (0.481-4.590)	0.491			1.800 (0.513-6.319)	0.359
Body mass index > 25 kg/m2	0.412 (0.071-3.902)	0.635			0.533 (0.063-4.480)	0.563
Symptomatic	0.144 (0.018-1.153)	0.068			1.994 (0.562-7.073)	0.285
EUS	2.067 (0.664-6.428)	0.210			1.641 (0.465-5.788)	0.442
FAP	15.167 (1.277-180.166)	0.031	9.363 (0.429-204.392)	0.155	4.650 (0.386-55.945)	0.226
Cholangiogram	1.550 (0.493-4.870)	0.453			3.983 (1.081-14.669)	0.038	2.235 (0.323-15.460)	0.415
Pancreatogram	0.278 (0.087-0.885)	0.030	0.534 (0.106-2.678)	0.446	2.338 (0.281-19.450)	0.432
Piecemeal resection	0.929 (0.187-4.606)	0.928			6.364 (1.661-24.375)	0.007	6.698 (1.599-28.057)	0.009
Thermal ablation	4.412 (1.366-14.250)	0.013	4.128 (1.005-17.128)	0.048	2.143 (0.570-8.052)	0.259
BDS	0.868 (0.222-3.393)	0.838			4.800 (1.323-17.418)	0.017	2.647 (0.398-17.619)	0.314
PDS	0.102 (0.030-0.349)	0.000	0.205 (0.044-0.945)	0.042	1.607 (0.325-7.951)	0.561
Size, > 15 mm	1.072 (0.308-3.731)	0.913			2.465 (0.690-8.812)	0.165
Initial pathology
Benign	Ref				Ref
LGD	0.975 (0.109-8.693)	0.982			0.293 (0.050-1.697)	0.171
HGD	2.333 (0.167-32.584)	0.529			0.429 (0.031-5.985)	0.529
Positive/uncertain resection margin	3.562 (1.086-11.685)	0.036			0.833 (0.167-4.167)	0.824

OR: Odds ratio; EUS: Endoscopic ultrasound; FAP: Familial adenomatous polyposis; BDS: Bile duct stent insertion; PDS: Pancreatic duct stent insertion; LGD: Low grade dysplasia; HGD: High grade dysplasia.