New insights in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

doi:10.3748/wjg.v28.i17.1751

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 7, 2022; 28(17): 1751-1767
Published online May 7, 2022. doi: 10.3748/wjg.v28.i17.1751

Table 1 World Health Organization classification for gastroenteropancreatic neuroendocrine neoplasms¹

	Differentiation	Mitotic rate (%)	Ki-67 proliferation index (%)

G1 NET	Well-differentiated	< 2	< 3
G2 NET	Well-differentiated	2-20	3-20
G3 NET	Well-differentiated	> 20	> 20
SCNEC	Poorly-differentiated	> 20	> 20
LCNEC	Poorly-differentiated	> 20	> 20
MiNEN	Well- or poorly-differentiated	Variable	Variable

NET: Neuroendocrine tumor; SCNEC: Small cell neuroendocrine carcinoma; LCNEC: Large cell neuroendocrine carcinoma; MiNEN: Mixed neuroendocrine-non-neuroendocrine neoplasm.

¹Data derived from Klimstra et al[1].

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Citation: Yin F, Wu ZH, Lai JP. New insights in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms. World J Gastroenterol 2022; 28(17): 1751-1767
URL: https://www.wjgnet.com/1007-9327/full/v28/i17/1751.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i17.1751

Yin F, Wu ZH, Lai JP. New insights in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms. World J Gastroenterol 2022; 28(17): 1751-1767 [PMID: 35633912 DOI: 10.3748/wjg.v28.i17.1751]

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