Update on the management of sigmoid diverticulitis

Table 4 Randomized controlled trials of antibiotics vs omission of antibiotics in the treatment of uncomplicated diverticulitis

Ref.	Number of patients	Antibiotics group	Control group	Primary outcome	Conclusions
AVOD[86]	623	At least 10 d of Abx, IV initially, then PO after admission or upon discharge	IV fluids	Complications, length of stay, need for surgery	Complications: 1% in Abx arm, 1.9% in control group (P = 0.302). LOS: 3 d in both groups. Recurrent diverticulitis/readmission in 1 year: 16% in both groups (P = 0.881)
DIABOLO[63]	528	10 d course of Abx, IV for 2 d, then PO	Observation as outpatient if clinical criteria satisfied	Time to recovery	Median time (d) to recovery: Observation 14 (IQR 6-35); antibiotic 12 (7-30; HR 0.91; P = 0.151)

Abx: Antibiotics; LOS: Length of stay; IQR: Interquartile range; HR: Hazard ratio; AVOD: Antibiotika Vid Okomplicerad Divertikulit.