Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways

Figure 6 Light photomicrographs of hepatic tissues. Hematoxylin and eosin stains, magnification 100 ×. A: Hepatic section of normal control rat exhibits normal architecture of hepatic cord of cells; B: Hepatic section of D-galactosamine/lipopolysaccharide (D-GalN/LPS) treated rats exhibiting massive fatty changes, focal central vein congestion, ballooning formation, necrosis with inflammation, and loss of cellular boundaries, massive cellular infiltration; C: Hepatic section of rats treated D-GalN/LPS and 20 mg/kg of sinapic acid (SA) showing mild central vein congestion, mild fatty changes, ballooning, necrosis with sinusoidal dilatation, mild cellular infiltration; D: Hepatic section of rats treated D-GalN/LPS and 40 mg/kg of SA exhibiting the absence of ballooning, inflammatory cells, and regeneration of hepatocytes around central vein toward near-normal liver architecture but slight congestion in the central vein.