Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice

Figure 7 Atropine and tetrodotoxin block the enhancement of antrum motility induced by Xiangbinfang granule. A-D: Intraperitoneal injection of 0.1 mg/kg atropine (ATR) completely blocked the enhancement effect of Xiangbinfang granule (XBF, 5 mg) on gastric antrum in wild-type (WT) (A) and W/W^v (C) mice. Tetrodotoxin (TTX) partially reduced the gastric antrum motility enhancement mediated by XBF in WT (B) and W/W^v (D) mice; E-F: Comparison of the effect of XBF 5 mg of antral contractile amplitude index in WT and W/W^v mice after pretreatment with ATR 0.1 mg/kg (E) and TTX 0.05 mg/kg (F). (n = 4, Welch’s t-test, ^aP < 0.05, ^bP < 0.01, ^cP < 0.001). WT: Wild-type; XBF: Xiangbinfang granule; TTX: Tetrodotoxin; CON: Basic control; ATR: Atropine.