Xiangbinfang granules enhance gastric antrum motility via intramuscular interstitial cells of Cajal in mice

Figure 1 Immunogenicity of c-kit positive cells in the gastric antrum of wild-type and W/W^v mice. The c-kit positive cells were observed under a confocal microscope. The unit volume was 424.3 µm × 424.3 µm × 6 µm ≈ 0.0011 mm³. A: Immunostaining images showing the networks of interstitial cells of Cajal myenteric plexus (ICC-MP) and intramuscular interstitial cells of Cajal (ICC-IM), respectively: The abundant c-kit positive ICC-MP network of gastric antrum in wild-type (WT) mice (Aa); the sparse c-kit positive ICC-MP network of the gastric antrum in W/W^v mice (Ab); c-kit positive ICC-IM network of the gastric antrum in WT mice (Ac); no ICC-IM network distribution in the antrum of W/W^v mice (Ad); B and C: The number of c-kit positive cells in ICC-MP and ICC-IM was compared in the gastric antrum of WT and W/W^v mice under unit volume (424.3 µm × 424.3 µm) (n = 10, ^cP < 0.001). ICC-MP: Interstitial cells of Cajal myenteric plexus; ICC-IM: Intramuscular interstitial cells of Cajal; WT: Wild-type.