Comparative study of indocyanine green-R15, Child-Pugh score, and model for end-stage liver disease score for prediction of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt

Table 2 Univariable and multivariable logistic regression analyses of post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy

Parameter	Univariable logistic regression			Multivariable logistic regression
	Regression coefficient	OR	P value	Regression coefficient	OR	P value
Age	0.53	1.055	0.006b	0.057	1.059	0.021a
Gender (F/M)	0.134	1.143	0.789
TIPS indication (variceal bleeding/ascites/bleeding combined with ascites/other)	0.147	1.159	0.522
Cirrhotic aetiology (viral/alcoholic/biliary/drug-induced/autoimmune)	0.053	0.761	0.437
Preoperative HVPG	0.019	1.019	0.502
Preoperative PPG	0.022	1.023	0.289
Stent size (7/8/10)	-0.975	0.377	0.019a
Puncture site of portal vein (left branch/bifurcation/right branch)	0.763	2.145	0.006b	0.566	1.762	0.018a
Child-Pugh score	0.027	1.027	0.022a	0.053	1.055	0.046a
Child-Pugh grade (A/B/C)	0.196	0.594	1.216
MELD score	0.256	1.291	0.020a	0.516	1.068	0.043a
ICG-R15	0.026	1.027	0.027a	0.028	1.029	0.031a
Total protein	-0.029	0.972	0.203
Total bilirubin	0.000	1.000	0.962
Creatinine	0.006	1.006	0.151
ALT	0.000	1.000	0.892
AST	0.003	1.003	0.232
ALP	0.002	1.002	0.248
Albumin	-0.058	0.94	0.1364
Serum potassium	0.233	1.262	0.689
Serum clozapine	0.007	1.007	0.864
Serum sodium	-0.035	0.965	0.395
WBC	0.047	1.049	0.544
Platelet count	-0.003	0.997	0.359
Hb	-0.001	0.999	0.908
BUN	0.084	1.087	0.025a	0.085	1.008	0.028a
NH3	0.025	1.025	0.044a	0.032	1.033	0.025a
APTT	-0.015	0.985	0.768
INR	-0.644	0.525	0.504
FIB	0.248	1.281	0.389
PT	-0.059	0.943	0.559

^aP < 0.05.

^bP < 0.01. TIPS: Transjugular intrahepatic portosystemic shunt; HVPG: Hepatic venous pressure gradient; PPG: Portal pressure gradient; MELD: Model for end-stage liver disease; ICG: Indocyanine green; ALT: Alanine aminotransferase; AST: Aspartate transaminase; ALP: Alkaline phosphatase; Hb: Hemoglobin; BUN: Blood urea nitrogen; APTT: Active partial thromboplastin; INR: International normalized ratio; FIB: Fibrinogen; PT: Prothrombin time; WBC: White blood cell.