Survivin-positive circulating tumor cells as a marker for metastasis of hepatocellular carcinoma

Figure 5 Effect of survivin silencing and overexpression on proliferation and invasion abilities of HepG2 cells. A: Cell proliferation was evaluated at 12 h, 24 h, 48 h, 60 h, and 72 h after transfection with the siRNA or lentivirus using the CCK8 assay (n = 5), and it was significantly higher in the survivin-overexpressing cells (^aP < 0.05); B: Invasion ability of cells was examined by transwell assay (n = 3). The invasive cell count was significantly higher in the survivin-overexpressing cells (^aP < 0.05).