Frontiers in antibiotic alternatives for Clostridioides difficile infection

Table 2 Recent clinical trials examining potential fecal microbiota transplantation for treatment of Clostridioides difficile infection

Current phase	Title	ClinicalTrials.gov Identifier	First posted
NA	Fecal microbiota transplantation for C. difficile infection	NCT01905709	July 23, 2013
	Immune response to FMT for C. difficile	NCT02797288	June 13, 2016
	Outcomes and data collection for fecal microbiota transplantation for the treatment of recurrent C. difficile	NCT03562741	June 19, 2018
	Fecal microbiota transplantation (FMT) for C. difficile (CEFTA)	NCT03712722	October 1, 2018
	Rescue fecal microbiota transplantation for national refractory intestinal infection	NCT03895593	March 29, 2019
	Safety and efficacy of fecal microbiota transplantation	NCT04014413	July 10, 2019
1	Fecal transplant for pediatric patients who have recurrent C. difficile infection (FMT)	NCT02134392	May 9, 2014
2	Stool transplants to treat refractory C. difficile	NCT02127398	April 30, 2014
	FMT versus antimicrobials for initial treatment of recurrent CDI	NCT02255305	October 2, 2014
	Fecal microbiota therapy for recurrent C. difficile infection	NCT02686645	February 19, 2016
	Phase II trial of fecal microbiota transplant (FMT) for VRE and CRE patients	NCT03643887	August 23, 2018
	Fecal microbiota transplantation (FMT) plus fidaxomicin for severe of fulminant C. difficile	NCT03760484	November 30, 2018
	Multicentre blinded comparison of lyophilized sterile fecal filtrate to lyophilized fecal microbiota transplant in recurrent C. difficile infection	NCT03806803	January 16, 2019
	FMT and bezltoxumab compared to FMT and placebo for patients with IBD and CDI (ICON-2)	NCT03829475	February 4, 2019
	PMT for severe-CDI	NCT03970200	May 31, 2019
	Penn microbiome therapy (PMT) for recurrent C. difficile infection	NCT03973697	June 4, 2019
3	Fecal transplantation for primary C. difficile infection (COLONIZE)	NCT03796650	January 8, 2019
	Microbiota restoration therapy for recurrent C. difficile infection (PUNCH CD3-OLS) (CD3-OLS)	NCT03931941	April 30, 2019
	Fecal microbiota transplantation for primary C. difficile diarrhea	NCT02801656	June 16, 2016

FMT: Fecal microbiota transplantation; C. difficile: Clostridioides difficile; PMT: Penn microbiome therapy.