Comprehensive radiomics nomogram for predicting survival of patients with combined hepatocellular carcinoma and cholangiocarcinoma

Table 2 Univariate analysis and multivariate Cox regression to identify clinical factors associated with overall survival after curative hepatectomy

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Male sex	0.470 (0.203-1.088)	0.078	1.767 (0.244-1.316)	0.186
Age, yr
≤ 60	Ref.
> 60	1.173 (0.644-2.139)	0.602
Liver cirrhosis
Absent	Ref.
Present	1.370 (0.852-2.203)	0.194
AFP (ng/mL)	0.990 (0.597-1.643)	0.970
CA 19-9 (U/mL)	0.987 (0.586-1.662)	0.960
Albumin (g/L)	2.496 (0.997-6.244)	0.051	1.025 (0.968-1.085)	0.403
TB (μmol/L)
≤ 34	Ref.		Ref.
> 34	17.994 (4.726-68.509)	< 0.001	13.943 (3.561-54.602)	< 0.001
Tumor number, multiple	0.766 (0.473-1.240)	0.277
Satellite lesions
Absent	Ref.		Ref.
Present	2.037 (1.267-3.268)	0.003	1.762 (1.079-2.877)	0.024
Vascular invasion
Absent	Ref.		Ref.
Present	2.009 (1.247-3.239)	0.004	1.725 (1.049-2.834)	0.032
T stage
T1	Ref.
T2	1.171 (0.705-1.942)	0.542
T3	2.424 (0.704-8.348)	0.161
T4	3.823 (1.158-12.615)	0.028
Anatomy resection
Yes	Ref.		Ref.
No	2.011 (1.344-3.006)	0.006	1.731 (1.083-2.767)	0.028
Margin
R0	Ref.
R1	1.032 (0.446-2.387)	0.941
Postoperative TACE
Yes	Ref.
No	1.597 (0.924-2.759)	0.093	1.6051 (0.3546-1.0947)	0.100

AFP: Alpha-fetoprotein; CI: Confidence interval; HR: Hazard ratio; Ref.: Reference; TB: Total bilirubin; TACE: Transhepatic arterial chemotherapy and embolization.