Role of human nucleoside transporters in pancreatic cancer and chemoresistance

Table 1 The current chemotherapeutic and chemoprotectant agents used to treat pancreatic cancer, their classification, action, and chemical structure

Drug	Classification	Action
Gemcitabine (Gemzar)	Antimetabolite	Pyrimidine antagonist
Doxorubicin (Rubex)	Anthracycline Antibiotic	Cell-cycle specific antagonist
Fluorouracil (5-FU)	Antimetabolite	Pyrimidine antagonist
Paclitaxel (Abraxane)	Plant alkaloid, Taxane, Antimircotubule	Inhibition of cell microtubule structures
Oxaliplatin (Eloxatin)	Alkylating agent	Cell-cycle non-specific antagonist
Leucovorin (Folinic acid)	Chemoprotectant	Enhancement anti-cancer effects
Irinotecan (Camptosar)	Plant alkaloid, Topoisomerase I inhibitor	Camptothecan analogs
Erlotinib (Tarceva)	Tyrosine kinase inhibitor	Ant-EGFR
Cetuximab (Erbitux)	Biologic	Anti-EGFR
Bevacizumab (Avastin)	Biologic	Anti-VEGF

Citation: National Center for Biotechnology Information, 2021 [cited 12 April 2021]. Database: PubChem Compound Summary [Internet]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Gemcitabine[70,71].