Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling

Figure 8 Schematic diagram depicting the role of extracellular matrix and extracellular matrix enzymes in promoting colorectal cancer pathogenesis. Comparison with the normal rats, rats exposed to cold and capsaicin with profound remodeling of extracellular matrix (ECM) in the colonic tissue, which was mediated by ECM enzymes. These results implicate a crucial role of ECM remodeling on cold and capsaicin exposure colorectal cancer development and progression. CRC: Colorectal cancer; DMH: 1,2-Dimethylhyrazine; MMP: Matrix metalloproteinase.