Fecal metabolomic profiles: A comparative study of patients with colorectal cancer vs adenomatous polyps

Table 3 Identified pathways from fecal water metabolites

Pathway analyses fecal water samples
Fecal metabolites		Metabolites	P	Holm P	FDR	Impact
AP	Valine, leucine and isoleucine biosynthesis	Leucine, valine	8.25 × 10-4	0.069	0.069	0.0
	Aminoacyl-tRNA biosynthesis	Valine, leucine, tyrosine	0.002	0.17	0.08	0.0
	Valine, leucine and isoleucine degradation	Leucine, valine	0.02	1	0.48	0.0
	Phenylalanine, tyrosine and tryptophan biosynthesis	Tyrosine	0.02	1	0.48	0.5
CRC	Aminoacyl-tRNA biosynthesis	Phenylalanine, valine, leucine, tyrosine	2.3 × 10-4	0.019	0.01	0
	Phenylalanine, tyrosine and tryptophan biosynthesis	Phenylalanine, tyrosine	2.7 × 10-4	0.022	0.035	1
	Valine, leucine and isoleucine biosynthesis	Leucine, valine	0.0012	0.1	0.035	0.0
	Phenylalanine metabolism	Phenylalanine, tyrosine	0.0019	0.16	0.041	0.36
	Galactose metabolism	Galactose, glycerol	0.014	1.0	0.2	0.05
	Valine, leucine and isoleucine degradation	Valine, leucine	0.03	1.0	0.43	0.0

An integrated analysis based on MetaboAnalyst 4.0 software built on significantly altered metabolites in colorectal cancer (CRC); and adenomatous patients (AP): View of most contributing pathways; P is the original P value calculated from the enrichment analysis; Holm P is the P value adjusted by Holm-Bonferroni method; the false discovery rate is the P value adjusted using false discovery rate (FDR); Impact is the pathway impact value calculated from pathway topology analysis.