Fecal metabolomic profiles: A comparative study of patients with colorectal cancer vs adenomatous polyps

Table 2 Summary of orthogonal projections to latent structures-discriminant analysis models built fecal water spectra acquired using selective one-dimensional proton nuclear magnetic resonance pulse sequences, sensitivity (%), specificity (%) and predictive accuracy (%) assessed following 100 runs of Monte Carlo cross-validation are reported for each model

	1H NMR fecal extract spectra OPLS-DA cv models
Group (n of samples)	Pulse sequences	Sensitivity (%)	Specificity (%)	Predictive accuracy (%)
HS (38) vs AP&CRC (41)	1D noesy; CPMG	84.9	85.7	85.3
HS (38) vs AP&CRC (41)		77.5	83.8	80.5
HS (38) vs CRC (26)	1D noesy; CPMG	94.2	90.2	93.7
HS (38) vs CRC (27)		97.3	85.2	91.0
HS (38) vs AP (15)	1D noesy; CPMG	90.8	76.6	87.0
HS (38) vs AP (14)		69.0	67.6	81.1
AP (15) vs CRC (26)	1D noesy; CPMG	77.0	90.4	79.3
AP (14) vs CRC (27)		67.5	74.0	72.7

AP: Adenomatous patients; CPMG: Carr-Purcell-Meiboom-Gill; CRC: Colorectal cancer.

¹HNMR: One-dimensional proton nuclear magnetic resonance; HCs: Healthy controls; OPLS-DA: Orthogonal projections to latent structures-discriminant analysis.