Increased systemic RNA oxidative damage and diagnostic value of RNA oxidative metabolites during Shigella flexneri-induced intestinal infection

Figure 2 Inflammatory cytokines interleukin-6, tumor necrosis factor-α, interleukin-1β, interleukin-17α, and interleukin-10 detected in serum samples of Shigellaflexneri infected rats. A: Interleukin (IL)-6; B: Tumor necrosis factor-α; C: IL-1β; D: IL-17α; E: IL-10. 0: Before infection. 1-18: The number of days after the establishment of the Shigella flexneri infection model. n = 12 per group on day 0 and day 1; n = 9 per group on day 5; n = 6 per group on day 9; n = 3 per group on day 18. Data are presented as the mean ± SEM. ^aP < 0.05; ^bP < 0.01; and ^cP < 0.001 (two-tailed unpaired Student’s t-test). PBS: Phosphate-buffered saline; IL: Interleukin; TNF: Tumor necrosis factor.