Review
Copyright ©The Author(s) 2021.
World J Gastroenterol. Sep 21, 2021; 27(35): 5851-5889
Published online Sep 21, 2021. doi: 10.3748/wjg.v27.i35.5851
Table 1 Genetic syndromes predisposing to pancreatic cancer (the frequency of mutated genes among patients with pancreatic ductal adenocarcinoma is indicated in brackets)
Genetic syndrome
Mutated genes
Hereditary breast/ovarian cancer syndrome[36,37]BRCA1 (0.7%), BRCA2 (1.4%), PALB2 (1%)
Familial atypical multiple mole melanoma syndrome[38]CDKN2A (0.7%)
Peutz-Jeghers syndrome[39]STK11
Familial adenomatous polyposisAPC (0.4%)
Lynch syndrome[40]MLH1, MSH2 (0.4%), PMS2 (0.3%)
Hereditary pancreatitis[41]PRSS1, SPINK1
Ataxia telangectasia[42]ATM (1.4%)
Li-Fraumeni syndrome[42]P53 (0.4%)