MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan

Table 7 Relationship between haplotypes of MTNR1B single-nucleotide polymorphism and 5-year overall survival of colorectal cancer patients

Haplotypes	Survival group (%)	Death group (%)	Crude		Adjusteda
			HR	95%CI	HR	95%CI
T-C-G-A	42.0	68.4	2.58	(1.27 to 5.28)	2.75	(1.82 to 11.2)
C-T-G-A	2.7	5.3	1.74	(0.42 to 7.26)	1.96	(0.44 to 8.66)
C-T-C-G	30.0	7.9	0.23	(0.07 to 0.76)	0.21	(0.06 to 0.71)
C-T-C-A	22.0	15.8	0.73	(0.30 to 1.76)	0.70	(0.28 to 1.72)

^aAdjusted for age, sex, stage, adjuvant chemotherapy, tumor location. The reference is the set of all the other haplotypes when one haplotype is regarded as an analyzed item. HR: Hazard ratio.