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©The Author(s) 2021.
World J Gastroenterol. Sep 14, 2021; 27(34): 5737-5752
Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5737
Published online Sep 14, 2021. doi: 10.3748/wjg.v27.i34.5737
Table 4 Relationship between MTNR1B single-nucleotide polymorphism and 5-year overall survival of colorectal cancer patients
| No. of subjects | No. of cases (%) | Crude | Adjusteda | |||
| HR | 95%CI | HR | 95%CI | |||
| rs1387153 (C>T) | ||||||
| CC | 23 | 2 (11.8) | 1.00 | Referent | 1.00 | Referent |
| CT | 48 | 7 (41.2) | 1.65 | (0.34 to 7.95) | 1.98 | (0.40 to 9.82) |
| TT | 21 | 8 (47.1) | 6.03 | (1.28 to 28.4) | 10.6 | (1.87 to 59.5) |
| TT vs CC + CT | 4.18 | (1.61 to 10.9) | 6.23 | (2.01 to 19.3) | ||
| rs2166706 (T>C) | ||||||
| TT | 22 | 2 (11.1) | 1.00 | Referent | 1.00 | Referent |
| TC | 49 | 7 (38.9) | 1.55 | (0.32 to 7.47) | 1.91 | (0.39 to 9.45) |
| CC | 23 | 9 (50.0) | 5.74 | (1.24 to 26.6) | 10.5 | (1.96 to 56.4) |
| CC vs TT + TC | 4.15 | (1.65 to 10.5) | 6.40 | (2.21 to 18.6) | ||
| rs10830963 (C>G) | ||||||
| CC | 21 | 2 (11.1) | 1.00 | Referent | 1.00 | Referent |
| CG | 49 | 6 (33.3) | 1.19 | (0.24 to 5.91) | 1.40 | (0.27 to 7.22) |
| GG | 23 | 10 (55.6) | 5.79 | (1.27 to 26.5) | 9.46 | (1.90 to 47.1) |
| GG vs CC + CG | 5.09 | (2.01 to 12.9) | 7.43 | (2.63 to 21.1) | ||
| rs1447352 (A>G) | ||||||
| AA | 50 | 14 (77.8) | 1.00 | Referent | 1.00 | Referent |
| GA | 37 | 4 (22.2) | 0.36 | (0.12 to 1.08) | 0.31 | (0.10 to 0.99) |
| GG | 6 | 0 (0) | N/A | N/A | N/A | N/A |
| AA vs GG + GA | 3.37 | (1.11 to 10.2) | 4.28 | (1.32 to 13.9) | ||
- Citation: Lee CC, Kuo YC, Hu JM, Chang PK, Sun CA, Yang T, Li CW, Chen CY, Lin FH, Hsu CH, Chou YC. MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan. World J Gastroenterol 2021; 27(34): 5737-5752
- URL: https://www.wjgnet.com/1007-9327/full/v27/i34/5737.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i34.5737