Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion

Figure 8 Beneficial effects of recombinant human angiopoietin-like protein 4 on angiopoietin-like protein 4 deficient Caco-2 cells challenged after hypoxia/reoxygenation. A: Cellular levels of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6 and malondialdehyde (MDA) levels; B: Myosin light chain kinase (MLCK), zonula occludens-1 (ZO-1) and claudin-2 (CLDN-2) levels; C: Microtubule-associated protein light chain 3II and cleaved caspase-3 levels were measured 4 h after reoxygenation (mean ± SD, n = 3). ^aP < 0.05, ^bP < 0.01 vs control; ^cP < 0.05 vs vehicle. H/R: Hypoxia/reoxygenation.