Circular RNA AKT3 governs malignant behaviors of esophageal cancer cells by sponging miR-17-5p

Figure 4 Circular RNA AKT3 knockdown suppressed growth of esophageal cancer in vivo. A: The expression of circular RNA AKT3 (circAKT3) in TE-1 cells with circAKT3 short hairpin (sh)RNA transfection; B and C: The size (B) and weight (C) of the xenograft tumor injected with circAKT3 shRNA-transfected TE-1 cells; D-G: The expression of circAKT3 (D), miR-17-5p (E), RHOC (F) and STAT3 (G) in the xenograft tumor injected with circAKT3 shRNA-transfected TE-1 cells by quantitative real time-polymerase chain reaction; H: The protein levels of RHOC and STAT3 in the xenograft tumor injected with circAKT3 shRNA-transfected TE-1 cells. ^cP < 0.001. sh-NC: Negative control shRNA; sh-circAKT3: Circular RNA AKT3 shRNA.