Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B

Table 2 Serum levels of 25-hydroxy vitamin D and vitamin-D-binding protein in different groups of children with chronic hepatitis B

Group (n)	25(OH)D, nmoL/L	Z/t/H value1	P value1	VDBP, μg/L	Z/H value1	P value1
HBeAg		1.70	0.091		3.81	< 0.001
Positive (164)	57.69 ± 18.06			106.95 (68.44-203.21)
Negative (40)	52.35 ± 16.73			257.23 (135.61-342.96)
HBV genotype2		0.32	0.753		2.51	0.012
Genotype B (131)	55.69 ± 17.63			105.00 (69.30-199.35)
Genotype C (23)	56.93 ± 17.69			75.40 (42.75-123.10)
HBsAg		1.77	0.076		4.32	< 0.001
Positive (193)	56.26 ± 18.17			113.87 (69.90-217.03)
Negative (11)	56.60 (54.37-72.96)			439.65 (259.27-510.45)
HBV DNA		0.77	0.441		4.75	< 0.001
Detectable (164)	57.12 ± 18.14			105.75 (66.39-193.73)
Undetectable (40)	54.69 ± 16.91			284.18 (152.64-406.14)
Fibrosis grades2		29.81	< 0.001		8.81	0.032
Grade 0 (27)	61.86 ± 13.63			90.00 (61.20-121.45)
Grade 1 (74)	54.97 ± 13.63			117.03 (65.74-275.76)
Grade 2 (12)	43.99 (35.79-55.15)			174.88 (121.34-292.94)
Grade 3 (9)	32.95 (28.61-35.20)			78.13 (35.05-176.75)

¹Normal distribution measurement data were analyzed by t test to determine the difference between two groups. For non-normal distribution measurement data, Mann-Whitney U test was used to compare serum levels of 25-hydroxy vitamin D and vitamin-D-binding protein between two groups, and Kruskal-Wallis H test was applied to analyze the difference among multiple groups.

²Statistical analysis was based on the actual number of completed cases because of the missing values. 25(OH)D: 25-hydroxy vitamin D; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus; VDBP: Vitamin-D-binding protein.