Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer

Figure 4 Effects of norcantharidin-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel on the cell cycle. The percentage of total cells in S and G2/M phases increased significantly with increasing norcantharidin (NCTD)-loaded metal-organic framework IRMOF-3 coated with temperature-sensitive gel (NCTD-IRMOF-3-Gel) concentration, and the proportion of cells in G0/G1 phase decreased significantly. A: Control group; B: 10 μg/mL; C: 20 μg/mL; D: 40 μg/mL. G1 phase: DNA presynthetic phase, where mitosis is complete before DNA replication begins; G2 phase: DNA synthesis replication phase, where DNA replication is complete before mitosis begins; M phase: Cell division phase; S phase: DNA synthesis replication phase.