Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

doi:10.3748/wjg.v27.i26.4045

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2021; 27(26): 4045-4087
Published online Jul 14, 2021. doi: 10.3748/wjg.v27.i26.4045

Table 6 Pancreatic cyst fluid biomarker studied in relation to high grade dysplasia and pancreatic cancer diagnosis

Type	Candidate marker
Protein	CEA[383,384,399,402-407], Glucose[385], MUC4[386,412], PGE2[387,388], IL-1B[386,387], PGE synthetase 2[386], IL-4[389], CA72-4[389], sFASL[389], MMP9[389] AREG[390,391], SPINK1[392], mAB Das-1[393,394], IL-10[395], GM-CSF[395], MUC1[413], MUC2[413], MUC5AC[413]
RNA	MiRNA: miR-21[396], miR-221[396], miR-18a[397,398], miR-24[397,398],miR-30a-3p[397,398], miR-92a[397,398], miR-99b[397,398], miR-106b[397,398], miR-142-3p[397,398], miR-342-3p[397,398], and miR-532-3p[397,398]
Other	DNA based-KRAS mutations[399-407,409-411] GNAS mutations[409-411]

MiRNA: MicroRNA; CA72-4: Cancer antigen 72-4; sFASL: Soluble Fas; AREG: amphiregulin; SPINK1: serine peptidase inhibitor kazal type 1; GM-CSF: granulocyte macrophage colony-stimulating factor.

Citation: O'Neill RS, Stoita A. Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket? World J Gastroenterol 2021; 27(26): 4045-4087
URL: https://www.wjgnet.com/1007-9327/full/v27/i26/4045.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i26.4045