Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?

doi:10.3748/wjg.v27.i26.4045

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2021; 27(26): 4045-4087
Published online Jul 14, 2021. doi: 10.3748/wjg.v27.i26.4045

Table 3 Serum based ‘liquid biopsy’ biomarkers implicated in the diagnosis of pancreatic cancer

	Biomarkers
Exosomes	Exosomes: GPC1[310,313], miR-10b[310], miR-30c[310], miR-181-a[310], miR-let7a[310], miR-17-5p[311], miR-21[311], miR-1246[312], miR-4644[312], miR-3976[312], miR-4306[312]
ctDNA	KRAS[314-317], ADAMTS1[318], BNC1[318]
CTC	CAPI+/CD45-[319], CK+[319], CEA+[319], CD45-/DAPI+/CEP8[320], CD45[321], CCK19[321], Pdx-1[321], Kras mutation[322], CEP8[323], CK[323], CD45[323], DAPI[323], chromosome 8[324], Folate-receptor positive CTCs[326]

Tspan8: Tetraspanin 8; EpCAM: Epithelial cell adhesion molecule; MET: mesenchymal-epithelial transition factor; CD104: Integrin 4-beta; GPC1: Glypican 1; GNAS: Guanine Nucleotide binding protein; KRAS: KRAS Proto-Oncogene, GTPase; ADAMTS1: A disintegrin and metalloproteinase with thrombospondin motifs 1; BNC1: Basonuclin 1; CD45: Leukocyte common antigen; CK19: Cytokeratin 19; Pdx-1: Pancreatic and duodenal homeobox 1; ADAMTS1: A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13; BNC1: Zinc finger protein basonuclin-1.

Citation: O'Neill RS, Stoita A. Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket? World J Gastroenterol 2021; 27(26): 4045-4087
URL: https://www.wjgnet.com/1007-9327/full/v27/i26/4045.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i26.4045