Review
Copyright ©The Author(s) 2021.
World J Gastroenterol. Jul 14, 2021; 27(26): 4018-4044
Published online Jul 14, 2021. doi: 10.3748/wjg.v27.i26.4018
Table 6 Hepatitis E virus highlights

Hepatitis E virus
1HEV is transmitted by the fecal-oral route (involving contaminated waters) and also as a zoonosis
2In the last years, many studies have focused on HEV detection in environmental and food matrices, and blood products as alternative sources of infection
3A new etiological agent of human hepatitis E, Orthohepevirus C, previously known to infect rats, has been recently described
4Although most cases of HEV infection produce acute hepatitis, chronic infections seem to be an increasing problem, particularly in Europe
5Complications and extrahepatic manifestations are also increasingly recognized
6Only one vaccine for HEV has been licensed in China, with little known data, which limits its use