Chronic hepatitis B in pregnant women: Current trends and approaches

doi:10.3748/wjg.v27.i23.3279

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2021; 27(23): 3279-3289
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3279

Table 3 Clinical features and vertical transmission risk in different phases of chronic hepatitis B

Phase of CHB	ALT	Fibrosis (Metavir score)	HBV DNA level	Markers of HBV-infection	Vertical transmission risk
Phase of immune tolerance	Normal	F0	Very high (10⁸-10⁹ IU/mL)	HBsAg+; HBeAg+; HBeAb-; HBcorAb+	Very high
Immunoreactive phase	Elevated	F1-F4	High (10⁶-10⁷IU/mL)	HBsAg+; HBeAg+/-; HBeAb-/+; HBcorAb+	High
Inactive carriage of HBsAg	Normal	F0	Less than 2000 IU/mL	HBsAg+; HBeAg-; HBeAb+; HBcorAb+	Low
Phase of HBeAg-negative CHB	Elevated	F1-F4	Middle (10³-10⁷IU/mL)	HBsAg+; HBeAg-; HBeAb+; HBcorAb+	Depends on HBV viral load
Occult CHB	Normal	F1-F4	+/-, HBV DNA in liver+	HBsAg-; HBeAg-; HBeAb-; HBcorAb+/-	Low

CHB: Chronic hepatitis B; ALT: Alanine aminotransferase; HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; HBeAB: Hepatitis B e antibody; HBcorAb: Hepatitis B core antibody.

Citation: Belopolskaya M, Avrutin V, Kalinina O, Dmitriev A, Gusev D. Chronic hepatitis B in pregnant women: Current trends and approaches. World J Gastroenterol 2021; 27(23): 3279-3289
URL: https://www.wjgnet.com/1007-9327/full/v27/i23/3279.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i23.3279