Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management

Table 3 The outcomes of various latest studies comparing laparoscopic pancreaticoduodenectomy with open procedure

Ref.	Study	Comparison	Outcome
Nickel et al[112], 2020	Meta-analysis of 3 RCTs	LPD and OPD	90-d mortality, post-operative complications and oncological outcomes were similar in both groups
			Blood loss was less for LPD
			Operating time was more for LPD
Yoo et al[113], 2020	Retrospective cohort study 359 patients	LPD and OPD	Post-operative complications and hospital stay were shorter for LPD
			Operative time was longer for LPD
			Recurrence free outcomes andoverall survival rates were similar
Chen et al[114], 2020	Meta-analysis of 6 cohort studies	LPD and OPD for PDA	Number of lymph nodes harvested, number of positive lymph nodes, rate of adjuvant therapy, time to adjuvant therapy, 1 yr survival and 2 yr survival are same for both the groups
Zhou et al[115], 2019	Retrospective cohort study	LPD and OPD	Overall complications and survival were similar between the two groups
Chen et al[116], 2018	Retrospective cohort study of 102 patients	LPD and OPD	Intra-operative blood loss, post-operative recovery and hospital stay were shorter for LPD
			Operative time was longer for LPD
			Post operative complications were similar in both the groups
Dang et al[117], 2020	Retrospective cohort study	LPD and OPD	Intra-operative blood loss, operating time and hospital stay for shorter for LPD
			30 d and 90 d mortality rates were better for LPD
			Long term survival rates were similar
Palanivelu et al[118], 2017	RCT of 68 patients with periampullary carcinoma	LPD and OPD	Intra-operative blood loss and hospital stay for shorter for LPD
			Operative time was longer for LPD
			Post-operative complications were similar in both the groups

RCT: Randomized control trial; LPD: Laparoscopic pancreaticoduodenectomy; OPD: Open pancreaticoduodenectomy.