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Copyright ©The Author(s) 2021.
World J Gastroenterol. Jun 14, 2021; 27(22): 3050-3063
Published online Jun 14, 2021. doi: 10.3748/wjg.v27.i22.3050
Table 1 Classification of the different stages of hepatic encephalopathy
Diagnostic criteriaClassification stages
ISHENUnimpairedCovert hepatic encephalopathyOvert hepatic encephalopathy
WHCMHEGrade IGrade IIGrade IIIGrade IV
No encephalopathy, no history of OHEImperceptible cognitive alterations during routine clinical examinationTrivial lack of awareness; Euphoria or anxiety; Shortened attention span; Impairment of addition or subtraction; Altered sleep rhythmLethargy or apathy; Disorientation for time; Obvious personality change; Inappropriate behavior; Dyspraxia asterixisSomnolence to semistupor; Responsive to stimuli; Confused; Gross disorientation; Bizarre behaviorComa