Repeatedly elevated γ-glutamyltransferase levels are associated with an increased incidence of digestive cancers: A population-based cohort study

Table 3 Incidence of site-specific digestive cancers according to the γ-glutamyltransferase points based on four consecutive examinations

	Esophagus		Stomach		Colorectal		Liver		Biliary		Pancreas
	IR per 1000	HR (95%CI)	IR per 1000	HR (95%CI)	IR per 1000	HR (95%CI)	IR per 1000	HR (95%CI)	IR per 1000	HR (95%CI)	IR per 1000	HR (95%CI)
Men
0	0.037	1 (reference)	0.772	1 (reference)	0.757	1 (reference)	0.215	1 (reference)	0.126	1 (reference)	0.293	1 (reference)
1	0.073	1.78 (1.45, 2.18)	0.968	1.12 (1.06, 1.19)	0.938	1.09 (1.03, 1.15)	0.505	2.39 (2.21, 2.59)	0.203	1.46 (1.29, 1.64)	0.389	1.18 (1.08, 1.28)
2	0.082	1.99 (1.58, 2.51)	1.011	1.18 (1.10, 1.25)	0.984	1.14 (1.07, 1.21)	0.624	3.13 (2.87, 3.41)	0.203	1.49 (1.30, 1.72)	0.392	1.19 (1.08, 1.32)
3	0.103	2.43 (1.97, 3.00)	1.063	1.22 (1.15, 1.29)	1.051	1.19 (1.12, 1.27)	0.727	3.74 (3.45, 4.06)	0.203	1.49 (1.30, 1.72)	0.425	1.27 (1.15, 1.40)
4	0.134	3.07 (2.61, 3.62)	1.127	1.26 (1.21, 1.33)	1.209	1.34 (1.28, 1.40)	1.293	6.89 (6.49, 7.32)	0.257	1.91 (1.72, 2.12)	0.501	1.48 (1.37, 1.59)
Women
0	0.005	1 (reference)	0.319	1 (reference)	0.534	1 (reference)	0.067	1 (reference)	0.065	1 (reference)	0.150	1 (reference)
1	0.007	1.00 (0.42, 2.39)	0.345	0.87 (0.77, 0.99)	0.651	0.99 (0.90, 1.08)	0.114	1.41 (1.12, 1.77)	0.102	1.12 (0.88, 1.42)	0.186	0.97 (0.81, 1.14)
2	0.008	0.92 (0.31, 2.74)	0.390	0.89 (0.77, 1.04)	0.720	0.99 (0.89, 1.11)	0.150	1.70 (1.32, 2.20)	0.138	1.30 (0.99, 1.70)	0.238	1.10 (0.90, 1.34)
3	0.009	1.01 (0.34, 3.02)	0.462	0.98 (0.84, 1.14)	0.804	1.03 (0.92, 1.16)	0.199	2.14 (1.66, 2.74)	0.162	1.36 (1.03, 1.78)	0.279	1.18 (0.96, 1.44)
4	0.014	1.38 (0.61, 3.12)	0.542	1.04 (0.92, 1.17)	0.924	1.06 (0.97, 1.17)	0.396	3.91 (3.25, 4.71)	0.203	1.45 (1.16, 1.80)	0.354	1.32 (1.13, 1.55)

Multivariate analysis was adjusted for age, smoking, drinking, income, hypertension, diabetes, dyslipidemia, body mass index and physical activity. IR: Incidence rate; HR: Hazard ratio; CI: Confidence interval.