Risk of hepatitis B virus reactivation in patients with autoimmune diseases undergoing non-tumor necrosis factor-targeted biologics

Table 1 The risk of hepatitis B virus reactivation in patients treated with interleukin-12/23 or interleukin-23 inhibitors

Ref.	Number of HBV patients	HBV status	Disease	Drugs	Prophylaxis	Follow-up	HBV reactivation
Ting et al[27], 2018	54	(1) 10 CHB; and (2) 44 resolved HBV. HBV-DNA at baseline (-)	Psoriasis	Ustekinumab	Yes: 2 patients with CHB	24 mo	(1) 2 patients with CHB without prophylaxis. (no hepatitis); and (2) 1 patient with resolved HBV (mild hepatitis)
Solay et al[5], 2018	29	29 resolved HBV. HBV-DNA at baseline (-)	Psoriasis/HS/AS/RA/CD	Ustekinumab (n = 7)	NA	22 wk	1 patient with psoriasis without prophylaxis (no data regarding hepatitis)
Sanz-Bueno et al[68], 2015	20	20 resolved HBV. HBV-DNA at baseline (-) but viral load was assessed in 7 of 20 patients	Psoriasis	Ustekinumab (n = 6)	No	40 mo	0
Chiu et al[28], 2013	14	(1) 11 CHB; and (2) 3 resolved HBV. HBV-DNA at baseline was not available	Psoriasis	Ustekinumab	Yes: 4 patients with CHB	10 mo	(1) 2 patients with CHB without prophylaxis (No hepatitis); and (2) 0
Navarro et al[69], 2013	5	5 CHB	Psoriasis	Ustekinumab (n = 1)	Yes	25 mo	0
Hayashi et al[70], 2014	5	5 resolved HBV. HBV-DNA at baseline was not available	Psoriasis	Ustekinumab	No	52 wk	0
Koskinas et al[41], 2013	1	Resolved HBV. HBV-DNA at baseline was not available	Psoriasis	Ustekinumab	No	16 mo	1 with hepatitis (ALT 65 IU/mL)
Steglich et al[71], 2014	1	Resolved HBV. HBV-DNA at baseline (-)	Psoriasis	Ustekinumab	Yes	36 mo	0
Duncan et al[43], 2019	1	Resolved HBV. HBV-DNA at baseline was not available	Palmoplantar Psoriasis	Guselkumab	No	12 mo	0

If a study included both of patients with chronic hepatitis B virus (HBV) and those with resolved HBV, we labeled the former with (1) and the latter with (2) in the column with HBV status. HBV: Hepatitis B virus; AS: Ankylosing spondylitis; CD: Crohn’s disease; CHB: Chronic HBV; HS: Hidradenitis suppurativa; RA: Rheumatoid arthritis; NA: Not available; ALT: Alanine transaminase.