Hypophosphatemia after high-dose intravenous iron treatment in patients with inflammatory bowel disease: Mechanisms and possible clinical impact

Table 3 Descriptive 36-item short form health survey scores for patient groups with/without hypophosphatemia independent of treatment group

SF-36 scale item	Normal phosphate population, baseline, mean ± SD	Hypophosphatemia population, baseline, mean ± SD	Difference1 at baseline, mean (95%CI)	Normal phosphate population, change at week 2, mean ± SD	Hypophosphatemia population, change at week 2, mean ± SD	Difference1 at week 2, mean (95%CI)	Normal phosphate population, change at week 6, mean ± SD	Hypophosphatemia population, change at week 6, mean ± SD	Difference1 at week 6, mean (95%CI)
General health	50.91 ± 20.1	48.50 ± 26.1	2.4 (-14.5 to 19.4)	-0.45 ± 12.9	0.75 ± 12.2	-1.2 (-9.2 to 6.8)	3.06 ± 16.3	3.25 ± 15.1	-0.2 (-10.2 to 9.8)
Physical functioning	78.72 ± 22.4	86.11 ± 21.1	-7.4 (-21.3 to 6.6)	2.63 ± 10.9	-0.28 ± 6.3	2.9 (-1.6 to 7.4)	3.97 ± 14.5	-0.28 ± 4.7	4.2 (0.2 to 8.3)
Role limitations due to physical problems	47.61 ± 42.8	66.67 ± 40.4	-19.1 (-45.7 to 7.6)	-4.08 ± 28.1	-6.25 ± 18.8	2.2 (-10.8 to 15.1)	11.32 ± 39.2	2.08 ± 16.7	9.2 (-3.7 to 22.1)
Bodily pain	65.65 ± 25.1	67.17 ± 27.6	-1.5 (-19.6 to 16.5)	0.68 ± 18.9	4.42 ± 12.2	-3.7 (-12.2 to 4.7)	3.40 ± 19.8	10.83 ± 19.1	-7.4 (-20.0 to 5.2)
Vitality	37.98 ± 22.0	40.00 ± 22.4	-2.0 (-16.7 to 12.7)	4.05 ± 13.1	7.50 ± 15.9	-3.4 (-13.8 to 6.9)	10.89 ± 18.0	12.92 ± 16.0	-2.0 (-12.7 to 8.6)
Mental health	71.72 ± 18.9	70.33 ± 16.9	1.4 (-9.9 to 12.6)	3.37 ± 9.0	4.33 ± 5.0	-1.0 (-4.5 to 2.6)	4.89 ± 13.2	1.67 ± 11.1	3.2 (-4.2 to 10.7)
Social functioning	68.35 ± 26.3	68.75 ± 30.4	-0.4 (-20.2 to 19.4)	3.86 ± 16.7	7.29 ± 13.5	-3.4 (-12.5 to 5.6)	8.70 ± 20.7	7.29 ± 15.5	1.4 (-9.1 to 11.9)
Role limitations due to emotional problems	67.91 ± 41.5	72.22 ± 42.2	-4.3 (-32.1 to 23.4)	-2.66 ± 34.8	-8.33 ± 37.9	5.7 (-19.1 to 30.5)	6.52 ± 38.0	-2.78 ± 26.4	9.3 (-8.8 to 27.4)

Hypophosphatemia defined as serum phosphate < 0.8 mmol/L (< 2.5 mg/dL).

¹Differences are normal phosphate group minus hypophosphatemia group. CI: Confidence interval; SF-36: 36-Item short form health survey.