Hepatocellular carcinoma progression in hepatitis B virus-related cirrhosis patients receiving nucleoside (acid) analogs therapy: A retrospective cross-sectional study

Table 3 Multivariate analysis of factors associated with hepatitis B-related cirrhosis progression to hepatocellular carcinoma in nucleos(t)ide analog-treated patients

Risk factor	β	SE	Wald	P value	OR (95%CI)
Age ≥ 60 yr	1.127	0.390	8.347	0.004	3.089 (1.437-6.631)
Smoking history	1.387	0.397	12.180	< 0.01	4.001 (1.836-8.716)
Family history of HBV-related HCC	1.911	0.860	4.938	< 0.05	6.763 (1.253-36.499)
LAM resistance	1.082	0.456	5.638	0.018	2.949 (1.207-7.208)
HBV DNA negative	-3.479	0.816	19.427	< 0.01	0.026 (0.007-0.139)
FBG ≥ 6.16 mmol/L	1.977	0.339	34.030	< 0.01	7.219 (3.716-14.024)

CI: Confidence interval; FBG: Fasting blood glucose; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; LAM: Lamivudine OR: Odds ratio;; SE: Standard error.