Exploration of nucleos(t)ide analogs cessation in chronic hepatitis B patients with hepatitis B e antigen loss

doi:10.3748/wjg.v27.i14.1497

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2021; 27(14): 1497-1506
Published online Apr 14, 2021. doi: 10.3748/wjg.v27.i14.1497

Table 3 Comparison of baseline clinical characteristics in the propensity score matching cohort

	HBeAg loss (n = 72)	HBeAg seroconversion (n = 72)	P values²
Age at cessation (yr)	31.8 ± 10.0	31.5 ± 11.8	0.873
Male, n (%)	49 (68.1)	48 (66.7)	0.859
Functional cure, n (%)	15 (20.8)	8 (11.1)	0.111
Pretreatment HBV DNA (log10 copies/mL)¹	7.14 (6.70-7.65)	7.00 (6.67-7.67)	0.781
Pretreatment ALT¹	151 (114-287)	200 (117-301)	0.394
Pretreatment AST¹	102 (69 -188)	122 (72 -204)	0.327
Consolidation periods (mo)¹	28 (21-40)	23 (15-37)	0.065
Time to HBeAg loss/conversion¹	12 (6-25)	15 (7-27)	0.566

¹median (IQR).

²t test, Mann-Whitney U test or χ² test. HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Citation: Xue Y, Zhang M, Li T, Liu F, Zhang LX, Fan XP, Yang BH, Wang L. Exploration of nucleos(t)ide analogs cessation in chronic hepatitis B patients with hepatitis B e antigen loss. World J Gastroenterol 2021; 27(14): 1497-1506
URL: https://www.wjgnet.com/1007-9327/full/v27/i14/1497.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i14.1497