Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation

Table 7 Independent risk factors for death identified by simple and multiple Cox regression

			All patients n = 240
Variables	Estimative	HR	95%CI	P value	HR	P value
		Univariate			Multivariate
Male gender	-0.062	0.94	0.514-1.718	0.841
Age (d)	-0.024	0.977	0.950-1.004	0.095
Weight (kg)	-0.17	0.844	0.738-0.964	0.012
Height (cm)	-0.044	0.957	0.924-0.990	0.013
WAZ	-0.243	0.784	0.623-0.986	0.037
HAZ	-0.085	0.918	0.734-1.148	0.455
WHZ	-0.235	0.791	0.649-0.963	0.019
BMIZ	-0.084	0.919	0.723-1.168	0.49
PELD score	0.022	1.022	0.982-1.064	0.282
Biliary Atresia	-0.426	0.653	0.357-1.195	0.167
Kasai surgery	-0.214	0.808	0.440-1.483	0.491
Infections ≤ 30 d pre-LT	0.348	1.416	1.023-1.960	0.036
eGFR (mL/min/1.73 m2)1	-0.005	0.995	0.991-0.999	0.010	0.995	0.023
Surgical time (hours)	0.012	1.013	0.856-1.197	0.884
Hemoglobin (g/dL)2	-0.206	0.814	0.657-1.008	0.059
INR2	0.259	1.295	0.722-2.322	0.386
Sodium (mEq/L)2	-0.014	0.986	0.916-1.061	0.704
Albumin (g/dL)2	-0.116	0.89	0.615-1.290	0.539
Lactate (mmoL/L)3	-0.021	0.979	0.914-1.048	0.541
GBWR (%)	0.149	1.16	0.909-1.481	0.232
RBC > 27.5 mL/kg	1.316	3.73	1.730-8.042	0.001	3.031	0.009
Presence of major complication	0.384	1.469	0.799-2.701	0.261

¹Estimated glomerular filtration rate, preoperative calculated by Schwartz's formula.

²Blood samples collected up to 72 h before liver transplantation (LT).

³Blood samples collected up to 2 h after the onset of LT anesthetic induction. WAZ: Weight-for-age z-score; HAZ: Height-for-age z-score; WHZ: Weight-for-height z-score; BMIZ: Body-mass-index-for-age z-score; PELD: Pediatric end-stage liver disease; LT: Liver transplantation; INR: International normalized ratio; GBWR: Graft-to-body-weight ratio; RBC: Red blood cells; eGFR: Estimated glomerular filtration rate; HR: Hazard ratio.