Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

Figure 2 TNBS treatment increased the levels of colon L-Kyn in absence of KMO. KP metabolite levels in the colon of the indicated mice were measured using HPLC. The data are represented as mean ± SE from at least four independent experiments: ^aP < 0.05 vs Vehicle or TNBS-treated KMO^+/+ mice group; ^bP < 0.01 vs Vehicle or TNBS-treated KMO^+/+ mice group; ^cP < 0.05 vs KMO^−/− Vehicle group; and ^dP < 0.01 vs Vehicle group. KMO: Kynurenine 3-monooxygenase; TNBS: Trinitrobenzene sulfonic acid.