Downregulation of orosomucoid 2 acts as a prognostic factor associated with cancer-promoting pathways in liver cancer

Figure 7 Decreased orosomucoid 2 is closely associated with immunosuppression in liver tumors. A: Correlation between orosomucoid 2 (ORM2) expression and tumor purity and, B: Infiltration levels of macrophage cells in liver tumor tissues were determined using The Cancer Genome Atlas (TCGA) liver cancer data by the TIMER portal. C and D: Gene correlation between ORM2 and tumor-associated macrophage-related markers (including CD68 and TGFβ1) were subjected to examination in the TCGA liver tumors, adjacent liver tissues and genotype-tissue expression portal (GTEx) liver tissues with the GEPIA portal. E-F: Correlation of ORM2 and immune checkpoints were evaluated in the TCGA liver tumors, adjacent liver tissues and GTEx liver tissues with the GEPIA portal. ORM2: Orosomucoid 2.