Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales

doi:10.3748/wjg.v26.i47.7538

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World Journal of Gastroenterology

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World J Gastroenterol. Dec 21, 2020; 26(47): 7538-7549
Published online Dec 21, 2020. doi: 10.3748/wjg.v26.i47.7538

Table 3 Results of hematological indices and serological (indirect and indirect) markers of liver fibrosis in examined patients

Parameter (reference range)	ALC					NAFLD					Controls
Parameter (reference range)	Mean	SD	Median	Min	Max	Mean	SD	Median	Min	Max	Mean	SD	Median	Min	Max
NLR	6.3	6.99	4.09^d	0.53	49.84	3.4	2.84	2.63^d	0.17	17.33	1.97	1.09	1.77	0.81	6.2
PLR	120.85	87.18	99.49^d	0.7	435.82	182.78	128.93	139.55	8.94	742.86	154.88	64.92	141.59	56.9	327.27
MPR	0.15	0.29	0.09^d	0.02	3.28	0.04	0.02	0.03	0.01	0.1	0.03	0.01	0.03	0.02	0.06
AAR	2.19	1.16	1.89^d	0.18	7.57	1.03	0.55	0.91^a	0.23	3.1	1.15	0.43	1.1	0.43	2.86
APRI	4.35	7.02	2.43^d	0.15	68.38	0.81	1.04	0.48^d	0.13	7.67	0.25	0.13	0.23	0.11	0.86
FIB-4	11.67	25.46	6.34^d	0.69	287.59	1.92	1.63	1.57^d	0.23	11.58	0.85	0.54	0.71	0.28	3.27
GPR	15.73	28.54	6.65^d	0.18	188.71	2.76	5.57	0.54^d	0.13	35.41	0.25	0.1	0.24	0.06	0.63
PICP (ng/mL)	63.32	31.53	60.53	6.15	161.12	52.14	27.56	46.08	10.10	147.27	58.26	37.39	44.18	0	202.89
PIIINP (ng/mL)	9.28	4.33	8.4^b	2.43	28.65	11.41	3.99	11.00	2.18	25.35	11.07	5.61	10.25	4.35	43.63
PDGF-AB (pg/mL)	18280.47	8061.06	17343.71^c	1925.68	42823.84	26858.68	7335.09	26682.83	10821.02	49808.07	23579.28	10068.8	25623.2	1638.2	47758.7
TGF-α (pg/mL)	24	45.33	13.77^d	0.872	507.09	17.89	19.18	12.09^d	1.39	142.63	28.44	17.21	24.59	1.31	93.55
Laminin (ng/mL)	976.34	705.29	832.06^a	101.933	3301.00	48	230.24	375.23^d	72.87	1335.92	718.24	386.1	663.27	140.88	1813.88

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

^dP < 0.0001. ALC: Alcoholic liver cirrhosis; NAFLD: Nonalcoholic fatty liver disease; SD: Standard deviation; Min: Minimum; Max: Maximum; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; MPR: Mean platelet volume-to-platelet-ratio; AAR: Aspartate transaminase to alkaline transaminase ratio; APRI: Aspartate transaminase to platelet ratio index; FIB-4: Fibrosis-4; GPR: Gamma-glutamyl transpeptidase to platelet ratio; PICP: Procollagen I carboxyterminal propeptide; PIIINP: Procollagen III aminoterminal propeptide; PDGF-AB: Platelet-derived growth factor AB; TGF-α: Transforming growth factor-α.

Citation: Michalak A, Cichoż-Lach H, Guz M, Kozicka J, Cybulski M, Jeleniewicz W, Stepulak A. Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales. World J Gastroenterol 2020; 26(47): 7538-7549
URL: https://www.wjgnet.com/1007-9327/full/v26/i47/7538.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i47.7538