Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review

Table 1 Characteristics of included original articles and meta-analyses

Ref.	Year	Study type	No of patients	GI etiology	No of males/females	Age	Study period
Bager et al[5]	2013	Retrospective	169	Nonvariceal AUGIB	86/83	70 (22-95)1	2009
Bager et al[44]	2014	Double-blind, randomized, placebo-control	97	Nonvariceal AUGIB	51/46	70 (23-95)2	2010-2013
Bager et al[50]	2014	Double-blind, randomized, placebo-control	97	Nonvariceal AUGIB	51/46	70 (67.4-73.1)3	-
Ballester et al[45]	2019	Retrospective, single-center	84	Acute GIB	58/26	68.0 (16.9)2	2012-2015
Bosch et al[51]	2017	Prospective cohort	2818	GI diseases known to cause GIB	1398/1420	63.4 (15.7)2	2015-2016
Bosch et al[29]	2017	Prospective cohort	4552	Occult bleeding	2266/2286	63.7 (17.6)2	2005-2015
Brooklyn et al[6]	2003	N/A	153	Occult bleeding	51/102	66 (45-96)2	2000
Cheng et al[52]	2010	Prospective	390	Ulcers	263/127	63 (16)2	-
El-Halabi et al[7]	2016	Retrospective, chart review, single-center	307	Any GIB	130/177	66.2 (18.6)2	2011-2012
Geisser et al[46]	2010	Phase I/II, multicenter, open-label, multiple-dose	46	Bleeding due to GI disorder	10/36	42.9 (11.0)2	2003-2004
Jairath et al[35]	2010	Meta-analysis	-	AUGIB	2731/1710	Early RBC 67.9 (16.51)2; no early RBC 63.4 (19.19)2	2007
Jairath et al[36]	2015	Pragmatic, multicentric, open-label, randomized feasibility trial	936	AUGIB	566/370	Liberal 60.4 (20.0)2; restrictive 58.0 (20.3)2	2012-2013
Restellini et al[31]	2013	Observational, registry-based	1677	Nonvariceal AUGIB	1035/642	66.2 (16.8)2	1999-2002
Rockey et al[32]	2017	Prospective cohort	1460	Acute or chronic GIB	899/561	53 (14)2	2006-2011
Salvadori et al[47]	2016	Retrospective	38	GI chronic blood loss	22/16	78 (54-94)4	2014-2015
Schröder et al[48]	2004	N/A	31	GI blood loss	12/19	43.8 (18.0)2	-
Subramaniam et al[30]	2016	Retrospective cohort	2360	Nonvariceal AUGIB	1505/852	70 (56-81)4	2008-2010
Villanueva et al[37]	2013	RCT	889	Severe AUGIB	-	-	2003-2009

¹The median (range).

²The mean (range) or mean (standard deviation).

³Mean (95% confidence interval).

⁴The median (Interquartile range). AUGIB: Acute upper gastrointestinal bleeding; GI: Gastrointestinal; GIB: Gastrointestinal bleeding; RBC: Red blood cell; RCT: Randomized controlled trial.