Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer

doi:10.3748/wjg.v26.i45.7173

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2020; 26(45): 7173-7190
Published online Dec 7, 2020. doi: 10.3748/wjg.v26.i45.7173

Table 1 Demographic and clinical information of participants included in the study

Feature	HCs (n = 38)	ADA patients (n = 33)	CRC patients (n = 46)	P value
Age (yr)	56.85 ± 10.99	61.18 ± 8.53	63.63 ± 11.39	0.095
Gender (male:female)	24:14	23:10	32:14	0.799
BMI (kg/m²)	23.86 ± 3.84	24.817 ± 3.31	23.66 ± 2.88	0.676
Smoking history (%)	10 (26.3)	15 (45.5)	17 (37.0)	0.241
Drinking history (%)	14 (36.8)	9 (27.3)	12 (26.1)	0.522
CRC of FDRs (%)	6 (21.4)	8 (24.2)	8 (17.4)	0.753

The data are presented as the mean ± SD. HC: Healthy control; ADA: Colorectal adenoma; CRC: Colorectal cancer; BMI: Body mass index; FDR: False discovery rate.

Citation: Sun XZ, Zhao DY, Zhou YC, Wang QQ, Qin G, Yao SK. Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer. World J Gastroenterol 2020; 26(45): 7173-7190
URL: https://www.wjgnet.com/1007-9327/full/v26/i45/7173.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i45.7173