Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome

Table 3 Levels of fecal bile acids in patients with diarrhea-predominant irritable bowel syndrome and controls

Bile acids in nmol/g	IBS-D patients, n = 55	Controls, n = 28	P value
CA	3037.66 (282.82, 6917.47)	20.19 (5.03, 1304.28)	< 0.001
CDCA	1721.86 (352.80, 2613.83)	57.16 (13.76, 1639.92)	< 0.001
DCA	2012.66 (232.57, 2659.34)	2159.78 (1676.03, 3094.08)	0.084
LCA	1621.65 (58.99, 2396.49)	2339.24 (1737.09, 2782.40)	0.002
UDCA	8.92 (2.33, 23.93)	17.21 (8.76, 33.48)	0.025
TCA	5.36 (0.62, 26.39)	0.72 (0.46, 2.11)	0.004
TCDCA	6.85 (1.54, 22.89)	1.41 (0.37, 3.58)	0.001
TDCA	1.53 (0.93, 8.08)	1.75 (0.86, 6.63)	1.000
TLCA	0.88 (0.57, 1.85)	1.03 (0.36, 2.80)	0.908
TUDCA	1.43 (0.68, 2.61)	0.37 (0.07, 1.23)	0.002
GCA	4.36 (2.31, 17.52)	2.23 (1.39, 3.55)	< 0.001
GCDCA	17.47 (5.61, 51.56)	5.17 (2.56, 10.51)	< 0.001
GDCA	3.32 (0.63, 10.63)	2.67 (1.44, 6.83)	0.867
GLCA	0.64 (0.39, 1.61)	0.91 (0.41, 1.28)	0.282
GUDCA	1.27 (0.56, 4.76)	0.65 (0.38, 0.87)	0.002
Total BAs	8227.35 (5218.49, 12464.03)	5220.28 (3971.35, 8272.29)	0.011
Unconjugated BAs	8197.73 (5135.49, 11622.72)	5183.71 (3945.65, 8253.23)	0.017
Conjugated BAs	55.28 (27.09, 198.08)	28.51 (9.68, 36.32)	0.002
Tauro-BAs	23.00 (5.03, 58.65)	6.34 (2.52, 18.05)	0.006
Glyco-BAs	28.03 (13.20, 69.07)	12.77 (6.18, 23.15)	< 0.001
CBA/UBA ratio	0.0080 (0.0036, 0.0172)	0.0035 (0.0019, 0.0058)	0.004
Primary BAs	5534.22 (672.24, 10546.54)	85.88 (27.08, 3197.10)	< 0.001
Secondary BAs	3759.10 (336.36, 4694.96)	4675.59 (3543.60, 5623.73)	0.009
PBA/SBA ratio	1.66 (0.22, 11.14)	0.02 (0.01, 0.57)	< 0.001

The bile acids data are presented as the median (Q1, Q3). The P value after FDR correction was presented in the table. BAs: Bile acids; CA: Cholic acid; CBA/UBA ratio: The ratio of conjugated BAs to unconjugated BAs; CDCA: Chenodeoxycholic acid; DCA: Deoxycholic acid; GCA: Glyco-cholic acid; GCDCA: Glyco-chenodeoxycholic acid; GDCA: Glyco-deoxycholic acid; GLCA: Glyco-lithocholic acid; GUDCA: Glyco-ursodeoxycholic acid; IBS-D: Irritable bowel syndrome with predominant diarrhea; LCA: Lithocholic acid; PBA/SBA ratio: The ratio of primary BAs to secondary Bas; TCA: Tauro-cholic acid; TCDCA: Tauro-chenodeoxycholic acid; TDCA: Tauro-deoxycholic acid; TLCA: Tauro-lithocholic acid; TUDCA: Tauro-ursodeoxycholic acid; UDCA: Ursodeoxycholic acid.