Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome

doi:10.3748/wjg.v26.i44.7046

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2020; 26(44): 7046-7060
Published online Nov 28, 2020. doi: 10.3748/wjg.v26.i44.7046

Table 3 Multivariate analysis of factors associated with nonalcoholic fatty liver disease

CAP cut-off 288 dB/m
Variable	Unadjusted OR	aOR
PCOS duration (per yr)	1.03 (0.94-1.14)	1.04 (0.92-1.17)
BMI (per Kg/m²)	1.31 (1.16-1.48)^b	1.31 (1.13-1.52)^b
HOMA-IR (per unit)	1.42 (1.14-1.78)^a	1.13 (0.90-1.41)
Hyperandrogenism (yes vs no)	3.68 (1.37-9.83)^a	5.32 (1.56-18.17)^a
Elevated ALT (yes vs no)	5.14 (1.87-14.12)^a	3.54 (1.10-11.47)^a
CAP cut-off 302 dB/m
Variable	Unadjusted OR	aOR
PCOS duration (per yr)	0.81 (0.33-2.00)	0.94 (0.83-1.07)
BMI (per Kg/m²)	1.12 (1.06-1.18)^b	1.33 (1.14-1.55)^b
HOMA-IR (per unit)	1.39 (1.14-1.70)^a	1.18 (0.95-1.46)
Hyperandrogenism (yes vs no)	1.28 (1.10-1.48)^a	3.54 (1.00-12.57)^a
Elevated ALT (yes vs no)	1.93 (1.32-2.84)^a	2.55 (0.80-8.14)

Odds ratios and 95% confidence intervals are shown for each variable analyzed in univariate and multivariate logistic regression analysis.

^aP < 0.05.

^bP < 0.001.

CAP: Controlled attenuation parameter; FAI: Free androgen index; HOMA-IR: Homeostasis model for assessment of insulin resistance; IU: International unit; aOR: Adjusted odds ratio; NAFLD: Nonalcoholic fatty liver disease; PCOS: Polycystic ovary syndrome.

Citation: Shengir M, Krishnamurthy S, Ghali P, Deschenes M, Wong P, Chen T, Sebastiani G. Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome. World J Gastroenterol 2020; 26(44): 7046-7060
URL: https://www.wjgnet.com/1007-9327/full/v26/i44/7046.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i44.7046