Role of doublecortin-like kinase 1 and leucine-rich repeat-containing G-protein-coupled receptor 5 in patients with stage II/III colorectal cancer: Cancer progression and prognosis

Table 4 Prognostic value, univariate and multivariate analyses of potential predictor for survival

Variables	HR	95%CI	P value
Univariate
Age (≤ 49 vs > 49 yr)	0.681	0.276-1.684	0.406
Gender (Male vs Female)	0.795	0.316-2.001	0.626
Depth of penetration (T3 vs pT4)	0.772	0.226-2.640	0.680
Lymph node
N0	1 (ref)
N1	2.774	0.839-9.170	0.094
N2	8.899	2.496-31.723	0.001
Tumor stage (TNM) (II vs III)	3.880	1.274-11.871	0.017
Differentiation (well/moderate vs poor/mucinous)	0.376	0.155-0.913	0.031
Tumour site
Left	1 (ref)
Right	0.798	0.221-2.880	0.731
Rectum	0.872	0.319-2.384	0.790
CEA (normal vs high)	0.245	0.101-0.595	0.002
CA19-9 (normal vs high)	3.569	1.477-8.621	0.005
MSI (MSS vs MSI)	0.047	0.000-3055.106	0.588
Recurrence (absent vs present)	8.038	3.070-21.050	0.001
Lung metastasis (absent vs present)	2.141	0.776-5.911	0.142
Liver metastasis (absent vs present)	2.216	0.734-6.689	0.158
DCLK1 (low vs high)	4.167	1.491-11.644	0.006
Lgr5 (low vs high)	2.575	1.030-6.438	0.043
DCLK1/Lgr5 (others1 vs high/high)	3.273	1.297-8.262	0.012
Multivariate
Tumor stage (TNM) (II vs III)	6.087	1.647-22.499	0.007
Differentiation (well/moderate vs poor/mucinous)	2.706	0.989-7.406	0.053
CEA (normal vs high)	4.363	1.346-14.136	0.014
CA19-9 (normal vs high)	1.078	0.362-3.208	0.893
Recurrence (absent vs present)	12.002	3.066-46.988	0.001
DCLK1 (low vs high)	4.272	1.005-18.167	0.049
Lgr5 (low vs high)	7.088	0.582-86.342	0.125
DCLK1/Lgr5 (others1 vs high/high)	0.593	0.039-9.085	0.708

¹Low/low low/high and high/low. HR: Hazard ratio; CI: Confidence interval; DCLK1: Doublecortin-like kinase 1; Lgr5: Leucine-rich repeat-containing G-protein-coupled receptor 5; TNM: Tumor-node-metastasis.