Epidemiology of perforating peptic ulcer: A population-based retrospective study over 40 years

Table 2 Factors associated with peptic ulcer perforation incidence rate ratios from 1978 to 2017. Data are presented as adjusted incidence rate ratios from Poisson regression with calendar year and age as covariates

	Male	P value	Female	P value
	IRR (CI)		IRR (CI)
Total peptic ulcer perforation
Calendar year	0.986 (0.970 to 1.001)	0.074	1.005 (0.988 to 1.023)	0.55
Age (per 5 yr)	1.040 (1.029 to 1.051)	< 0.001	1.060 (1.047 to 1.073)	< 0.001
Gastric ulcer perforation
Calendar year	0.979 (0.956 to 1.001)	0.063	0.998 (0.973 to 1.024)	0.90
Age (per 5 yr)	1.037 (1.022 to 1.053)	< 0.001	1.056 (1.038 to 1.075)	< 0.001
Duodenal ulcer perforation
Calendar year	0.992 (0.971 to 1.014)	0.49	1.011 (0.988 to 1.035)	0.36
Age (per 5 yr)	1.043 (1.028 to 1.058)	< 0.001	1.063 (1.045 to 1.080)	< 0.001

IRR: Incidence rate ratio; CI: Confidence interval.