Golgi protein-73: A biomarker for assessing cirrhosis and prognosis of liver disease patients

doi:10.3748/wjg.v26.i34.5130

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2020; 26(34): 5130-5145
Published online Sep 14, 2020. doi: 10.3748/wjg.v26.i34.5130

Table 2 Baseline demographic, clinical and laboratory characteristics of patients according to golgi protein 73positivity

	GP73-positive (n = 277)	GP73-negative (n = 355)	P value
Age, median (IQR), yr	59 (15)	55 (22)	< 0.001
Sex, male/female, n (%)	169/108 (61/39)	207/148 (58.3/41.7)	0.545
INR, median (IQR)	1.28 (0.36)	1.09 (0.23)	< 0.001
Platelets, median (IQR), x10³/μL	125 (99.3)	180 (113.7)	< 0.001
AST, median (IQR), U/L	59 (67)	40 (44)	< 0.001
ALT, median (IQR), U/L	43 (45)	39 (43)	0.127
γ-GT, median (IQR), U/L	105 (171)	45 (79)	< 0.001
ALP, median (IQR), U/L	111 (80)	85 (66)	< 0.001
Bilirubin, median (IQR), mg/dL	1.9 (3.1)	0.9 (0.9)	< 0.001
Albumin, median (IQR), g/dL	3.4 (1.1)	4.3 (0.9)	< 0.001
AFP, median (IQR), ng/mL	5 (14.4)	3.5 (5)	< 0.001
APRI score, median (IQR)	1.4 (2.1)	0.6 (1)	< 0.001
Fibrosis stage (METAVIR) F0, F1 / ≥ F2, n (%)	4/28 (12.5/87.5)	92/72 (56.1/43.9)	< 0.001
Cirrhosis, yes/no, n (%)	267/10 (96.4/3.6)	183/172 (51.5/48.5)	< 0.001
Decompensation of cirrhosis, yes/no, n (%)	161/106 (60.3/39.7)	65/118 (35.5/64.5)	< 0.001
HCC, yes/no, n (%)	51/226 (18.4/81.6)	28/327 (7.9/92.1)	< 0.001
HCC BCLC stage, 0/A/B/C/D, n (%)	1/12/11/18/9 (2/23.5/21.6 /35.3/17.6)	1/11/11/3/1¹ (3.7/40.7/40.7 /11.1/3.7)	0.029
HCC BCLC stage, 0-A-B/ C-D, n (%)	24/27 (47.1/52.9)	23/4¹ (85.2/14.8)	0.002
HCC dimensions (very early/intermediate/advanced), n (%)	1/19/31 (2/37.3/60.8)	1/13/13¹ (3.7/48.1/48.1)	0.543

¹One missing case because diagnosis set on autopsy. GP73: Golgi protein 73; IQR: Interquartile range; INR: International normalized ratio; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γ-GT: γ-glutamyl transpeptidase; ALP: Alkaline phosphatase; AFP: Alpha-fetoprotein; APRI: AST to platelet ratio index; HCC: Hepatocellular carcinoma; BCLC: Barcelona clinic liver cancer.

Citation: Gatselis NK, Tornai T, Shums Z, Zachou K, Saitis A, Gabeta S, Albesa R, Norman GL, Papp M, Dalekos GN. Golgi protein-73: A biomarker for assessing cirrhosis and prognosis of liver disease patients. World J Gastroenterol 2020; 26(34): 5130-5145
URL: https://www.wjgnet.com/1007-9327/full/v26/i34/5130.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i34.5130