Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

Table 1 Selected proteins whose content is significantly modified in hepatocytes by Arachidyl amido cholanoic acid

Accession	Protein name	P value	Fold change achol/ctrl
Fibrosis
P20152	Vimentin GN = Vim PE = 1 SV = 3	6.29E-04	0.13
Q8BTM8	Filamin-A GN = Flna PE = 1 SV = 5	2.02E-02	0.45
Translation
Q9D7S7	60S ribosomal protein L22-like 1 GN = Rpl22l1 PE = 1 SV = 1	3.86E-02	0.42
P23116	Eukaryotic translation initiation factor 3 subunit A GN = Eif3a PE = 1 SV = 5	3.10E-03	0.59
Q9CZD3	Glycine-tRNA ligase GN = Gars PE = 1 SV = 1	6.87E-03	0.63
Lipid droplet clearance & FA oxidation
Q9DBG5	Perilipin-3 GN = Plin3 PE = 1 SV = 1	3.09E-02	0.51
E9Q414	Apolipoprotein B-100 GN = Apob PE = 1 SV = 1	3.50E-02	1.65
Q64337	Sequestosome-1 GN = Sqstm1 PE = 1 SV = 1	2.90E-02	5.01
P97742	Carnitine O-palmitoyltransferase 1 liver isoform GN = Cpt1a PE = 1 SV = 4	3.02E-02	1.32
Q99JY0	Trifunctional enzyme subunit beta mitochondrial GN = Hadhb PE = 1 SV = 1	1.40E-02	1.38
Q8BMS1	Trifunctional enzyme subunit alpha mitochondrial GN = Hadha PE = 1 SV = 1	1.78E-02	1.42
TCA cycle
P08249	Malate dehydrogenase mitochondrial GN = Mdh2 PE = 1 SV = 3	6.58E-03	1.46
Q9Z2I8	Succinate-CoA ligase (GDP-forming) subunit beta mitochondrial GN = Suclg2 PE = 1 SV = 3	1.52E-03	1.55
Q9Z2I9	Succinate-CoA ligase (ADP-forming) subunit beta mitochondrial GN = Sucla2 PE = 1 SV = 2	5.11E-03	1.87
OxPhos & antioxidant response
Q91VD9	NADH-ubiquinone oxidoreductase 75 kDa subunit mitochondrial GN = Ndufs1 PE = 1 SV = 2	4.28E-03	1.41
Q9DB77	Cytochrome b-c1 complex subunit 2 mitochondrial GN = Uqcrc2 PE = 1 SV = 1	6.36E-03	1.41
Q921G7	Electron transfer flavoprotein-ubiquinone oxidoreductase mitochondrial GN = Etfdh PE = 1 SV = 1	3.06E-02	1.43
Q9DC69	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 mitochondrial GN = Ndufa9 PE = 1 SV = 2	1.26E-02	1.54
Q91YT0	NADH dehydrogenase (ubiquinone) flavoprotein 1 mitochondrial GN = Ndufv1 PE = 1 SV = 1	1.92E-03	1.58
O09111	NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11 mitochondrial GN = Ndufb11 PE = 1 SV = 2	4.61E-02	1.89
P24270	Catalase GN = Cat PE = 1 SV = 4	4.84E-03	1.28
Q9DCM2	Glutathione S-transferase kappa 1 GN = Gstk1 PE = 1 SV = 3	3.31E-02	1.43
P20852	Cytochrome P450 2A5 GN = Cyp2a5 PE = 2 SV = 1	9.73E-03	4.29

See text for experimental details.