Acute liver failure and death predictors in patients with dengue-induced severe hepatitis

Table 3 Regression analysis of the factors associated with death from dengue-induced severe hepatitis

Parameters	Univariate analysis			Multivariate analysis
	Odds ratio	95%CI	P value	Adjusted odds ratio	95%CI	P value
Baseline demographic information
Age	1	1.0-1.1	0.817	1	1.0-1.1	0.142
Male sex	0.9	0.3-2.9	0.807	-	-	-
Hematological parameters change with response to dengue severity
Hematocrit	1	0.9-1.1	0.96	-	-	-
WBC count	1	1.0-1.0	0.856	-	-	-
Percentage of neutrophils	1.1	1.0-1.1	0.036a	-	-	-
Percentage of atypical lymphocytes	1	0.9-1.1	0.467	-	-	-
Platelet count	1	1.0-1.0	0.673	-	-	-
Liver status at diagnosis of DISH
Total bilirubin	1	0.9-1.1	0.789	0.8	0.5-1.3	0.347
SGPT	1	1.0-1.0	0.004b	-	-	-
INR	6.5	2.6-16.2	< 0.001c	10.4	2.6-40.5	0.001d
Albumin	0.2	0.1-0.5	0.003e	0.2	0.04-1.3	0.104
Creatinine	1.6	1.01-2.4	0.046f	1.2	0.8-1.9	0.419
MELD score	1.1	1.1-1.2	0.001g	-	-	-
Presence of liver comorbidity	1	0.1-8.2	0.983	-	-	-

^aP < 0.05.

^bP < 0.005.

^cP < 0.001.

^dP = 0.001.

^eP < 0.005.

^fP < 0.05.

^gP = 0.001. DISH: Dengue-induced severe hepatitis; WBC: White blood cell; INR: International normalized ratio; SGPT: Serum glutamate-pyruvate transaminase; MELD: Model for End-Stage Liver Disease; CI: Confidence interval.