Promising xenograft animal model recapitulating the features of human pancreatic cancer

Figure 2 ZZU001 Syrian hamsters demonstrate abnormal lymphoid cell development and impaired immune function. A: The thymus and spleen of interleukin 2 receptor subunit gamma (IL2RG) knock-out (KO) hamsters were both evidently smaller than those of age-matched interleukin 2 receptor subunit gamma +/- and wild type (WT) hamsters; B: Comparison of spleen-to-body weight ratio. Each value represents the mean ± standard deviation (n = 3/group), Student’s t-test. ^bP < 0.01; and C: Dye labeling of Syrian hamster lymph nodes (LNs) and lymphatic vessels. Efferent lymphatic vessel (orange arrowhead). Axillary LN, Inguinal LN, and Renal LN (orange arrow) are LNs.